Cyclin-Dependent Kinase Inhibitors in Cancer Therapeutics
نویسندگان
چکیده
منابع مشابه
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Cyclin-dependent kinases (CDKs) have been considered promising drug targets for a number of years, but most CDK inhibitors have failed rigorous clinical testing. Recent studies demonstrating clear anticancer efficacy and reduced toxicity of CDK4/6 inhibitors such as palbociclib and multi-CDK inhibitors such as dinaciclib have rejuvenated the field. Favorable results with palbociclib and its rec...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2020
ISSN: 1948-5875,1948-5875
DOI: 10.1021/acsmedchemlett.0c00635